Covid-19 Treatment And Drugs

CORONAVIRUS SHORT NEWS:

In Australia has created a drug that suppresses coronavirus in 48 hours! The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro. Highlights: -Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro; -A single treatment able to effect approximately 5000-fold reduction in virus at 48h in cell culture; -Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing; -Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.

- Russian scientists conducted a study and found that water treated with cold plasma is able to effectively fight bacteria, fungi and viruses, including COVID-19.

- Russian scientists, together with Mexican colleagues, conducted a study in which they discovered a new way to help extend the life of medical masks.

- Seattle's Infectious Disease Research Institute and a New Jersey company called Celularity have been cleared by the Food and Drug Administration to start trials of an experimental cell-based therapy for COVID-19.

- Henry Ford Health System to conduct first large US study of hydroxychloroquine's ability to prevent COVID-19.

- Fingolimod An approved drug called fingolimod (marketed under the brand name Gilenya for the treatment of relapsing forms of multiple sclerosis) is being studied as a treatment for COVID-19 at the First Affiliated Hospital of Fujian Medical University in Fuzhou, China...

- Antibodies in the blood of COVID-19 survivors know how to beat coronavirus - and researchers are already testing new treatments that harness them...

- A new coronavirus test can accurately diagnose people without disease symptoms...

- Employees of the Novosibirsk Scientific Center for Virology and Biotechnology "Vector" have created a test system for immunity to coronavirus infection. The test system may appear on the market by April 10-15...

- FDA authorizes use of antimalarial drugs for coronavirus treatment. According to the FDA, anecdotal reports suggest that hydroxychloroquine and chloroquine may offer some benefit for patients in serious condition...


A new study lead by one of China's to respiratory specialists, Dr Cao Bin, Professor at Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital has shown that Lopinavir-Ritonavir is ineffective in treating Covid-19.

The research involved 199 patients in Wuhan who had severe cases of laboratory-confirmed Covid-19 for a randomized, controlled trial.

Covid-19

Of those, 99 received Lopinavir-Ritonavir while 100 were only given standard care.

The HIV antiviral that works by stopping viruses from replicating had no observable effect on viral shedding in Covid-19 patients, suggesting it does not fight the virus that causes the condition. Two-fifths of patients in the Lopinavir-Ritonavir group continued to test positive for the virus at the end of the trial.

Those treated with the drug were also more likely to experience side effects like nausea, vomiting and diarrhea, which were so severe in 13 patients that they had to stop treatment.

Lopinavir-Ritonavir is a HIV drug from Abbvie Pharmaceuticals that goes by the trade name Kaletra or Aluvia.

In the early stages of the Covid-19 breakout in Wuhan, certain Chinese doctors were using it along with alpha-interferon to treat the disease but they were not much success. Even assumptions that the antiviral resistance to the drug was considered at those stages when in reality it had no efficacy.

Experts at those stages felt that as Lopinavir/ritonavir was already an approved HIV drug, it would have been easier to repurpose it for Covid-19.

Many governments had stockpiled the drug and also Chinese businessmen had even bought the drug at inflated prices from generic suppliers in India at prices that were inflated by as much as 30 times!

Dr Tony Cunningham, an expert in antiviral drugs and HIV treatment at a hospital in Sydney that is treating coronavirus patients, described its use as a "move of desperation."

He said, "The protease of HIV and the proteases of (the Covid-19 virus) are very different in structure and sequence, so it's not surprising that this did not work."

Also it must be noted that many HIV antiviral drugs are highly toxic and can cause a lot of adverse effects and chronic medical problems with long term usage.

The research was published in the New England Journal Of Medicine.
(https://www.nejm.org/doi/full/10.1056/NEJMoa2001282)

EU urges restraint with using malaria drugs to treat COVID-19

Malaria drugs should not be used to treat COVID-19 cases unless it is deemed absolutely necessary, the EU warned. Shortages of the drugs, which are also used to treat autoimmune disorders, have already hit the US.

Facing potential malaria drug shortages, the European Medicine Agency (EMA) urged countries on Wednesday to use the medicines sparingly to treat COVID-19.

The anti-malarial drugs hydroxychloroquine and chloroquine should only be sued in clinical trials or in "national emergency programs," the EMA said in a statement.

With a COVID-19 vaccine likely still months away, the drugs are being tested in several countries for their ability to treat the deadly and highly-contagious virus.

Despite early success in trials in China and France, the EMA emphasized that their "efficacy in treating COVID-19 is yet to be shown in studies."

 

 

 

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